The ongoing projects are listed below. The projects that have been completed and published are shown the Publications webpage.
Global Analysis of Clinical Integrated Epidemiology Research for Small Cell Lung Cancer (GLACIERS). Lead: Geoffrey Liu, Nuria Zellweger, Rayjean Hung
HLA functional analysis in lung cancer: Early-onset and never-smoking populations across ancestries. Lead: David Christiani, Xinan Wang
Genetics of EGFR mutation. Leads: David Christiani, Xinan Wang
Air pollution and lung cancer prognosis. Lead: Kiera Murison, Rayjean Hung
Survival association analysis of lung cancer in LORD. Lead: Yohan Bosse
GenExposomics and autophagy polygenic score. Lead: Baharia Mograbi, Chris Amos, Olga Gorlova
ADH1B and ALHD SNP's and LC Risk. Lead: Ming-Tsang Wu
Evaluating Sex Disparities in Lung Cancer Risk. Lead: Adam Reynolds, Chris Amos
Smoking and Comorbidities on Lung Cancer Survival. Lead: Adrew Lam, Geoffrey Liu
Genetic risk and menthol smoking. Lead: Stephanie Jones and Chris Amos
Investigating the association between the genetically proxied effects of drugs targeting cardiometabolic traits and hormonal therapy and lung cancer survival. Leads: Tessa Bate, Philip Haycock, James Yarmolinksy
Ancestry inference estimation methods to identify new susceptibility loci contributing to lung cancer. Leads: Hyeyeun Lim, Jinyoung Byun, Chris Amos
Leveraging age-at-onset in multi-ethnic genome-wide association study to identify novel loci in lung cancer. Leads: Yafang Li, Chris Amos, Yohan Bosse
Characterization of Extreme Phenotypes of Lung Cancer Risk. Leads: Jose Luis Perez-Gracia, Luis Montuenga
Prognostic Factors for NSCLC by Stage. Leads: Geoffrey Liu
Prognostic Factors for SCLC. Leads: Geoffrey Liu
Identifying shared proteomic risk factor. Lead: James Yarmolinsky
Develop multi-ancestry polygenic risk scores for lung cancer risk. Lead: Haoyu Zhang, Rayjean Hung, Xihong Lin, Chris Amos, Byun Jinyoung, Li-Shiun Chen, Laura Bierut
The changing demographics and outcomes in older patients with lung cancer over time. Lead: Geoff Liu, Wei Xu, Elizabeth Faour, Shabbir Alibhai, Cathi Brown
Impacts of long term smoking cessation and risk of lung cancer. Lead: James McKay, Lani Park, John Field, David Christiani, Chris Amos
Identifying circulating proteins that are a causal consequence of genetic liability to poor prognosis using reverse MR. Leads: Philip Haycock, Rayjean Hung, Geoffrey Liu, Karl Smith-Byrne, James Yarmolinsky
Characterization of genetic and epidemiologic architecture stratified by the stages of lung cancer in GWAS. Lead: Jinyoung Byun, Chris Amos
Association of epidemiological and genetic variables with tumor size at diagnosis in non-small cell lung cancer. Lead: Olga Gorlova, Christopher Amos, Rayjean Hung
Comprehensive investigation of lipidomics in lung cancer risk and prognosis. Lead: Beiwen Wu, Rayjean Hung, Geoffrey Liu, Chris Amos et al
Cardiorespiratory fitness, physical activity, and sleep in relation to lung cancer risk using a Mendelian randomization approach. Lead: Eleanor Watts et al, NCI, Cambridge
Evaluation of lung cancer PRS transferability from the perspective of uncertainty in individual PRS. Lead: Xinan Wang, David Christiani, Xihong Lin et al
Reliable PRS estimation improves the prediction performance of lung cancer risk. Lead: Xinan Wang, David Christiani, Xihong Lin et al
Using germline risk variants to understand interactions between cancer and the immune system. Lead: Xin He, Rayjean Hung, Aida Ferreiro et al
Identifying germline risk variants to understand risk of lung cancer and smoking cessation measures in former smokers. Lead: Lani Park et al
The association of blood protein biomarkers with lung cancer incidence and survival: a joint Mendelian Randomization and nested case-control study. Lead: Karl Smith Byrne, Mattias Johansson et al
Examining the genetic overlap of tobacco use, cannabis use and use disorder, and lung cancer. Lead: Arpana Agrawal, Laura Beirut et al
Genetic landscape analysis of short tandem repeats on the risk and survival of lung cancer. Lead: Mulong Du, David Christiani
Mendelian randomization studies of sleep traits and lung cancer risk. Lead: Brigid Lynch, Suzanne Dizon-Suen, James McKay et al
Circulating vitamin E levels and multiple cancers risk: A Mendelian randomization analysis. Lead: David Christiani et al
Machine learning methods to identify genetic variants and risk factors that discriminate between never smoking cases and controls. Lead: Monica Reyes, Matthew Schabath et al
Investigating the causal role of genetic variation in white blood cell traits in lung cancer etiology and prognosis. Lead: Linda Kachuri, Rayjean Hung
LD Score Analysis of Lung Cancer using Multi-Traits from UK Biobank. Lead: Jacob Edelson, Chris Amos et al
Evaluating genetic, clinical, and environmental risk factors for second primary lung cancer. Lead: Summer Han
Genetic architecture of lung cancer using machine-learning approaches in genome-wide association studies. Lead: Jinyoung Byun, Chris Amos
Genes related to Genetic And Rare lung Diseases (GARD) as risk for LC. Lead: Albert Rosenberg
Appraising the causal relevance of DNA methylation in lung cancer through two-sample Mendelian randomization. Lead: Rebecca Richmond, Caroline Relton et al
Genetic contributions to lung cancer risk conveyed through inflammatory and immune pathways. Lead: David Christiani
Genetic variant associated with mosaic chromosome alterations. Lead: Chao Cheng, Christopher Amos, James McKay
Mendelian randomization study of circulatory microRNAs and risk of lung cancer. Lead: Kostas Tsilidis, Sarah Chen, Rima Mustafa, Marina Evangelou, Mohsen Ghanbari, Rayjean Hung, Abbas Dehghan
Mendelian randomization study of allometric anthropometric indices and risk of lung cancer. Lead: Sofia Christakoudi, Emmanouil Bouras, Eleni Boutsikari, Chris Amos, Kostas Tsilidis
Identifying germline risk variants to understand risk of lung cancer and smoking cessation measures in former smokers. Lead: S. Lani Park, L. Le Marchand, D. Stram, C. Amos, J. McKay
Detecting racial disparities in cancer survival by integrating multiple high-dimensional observational studies. Lead: Y. Li, S. Guha, D. Christiani
Illicit drug abuse (opium, cocaine, crack cocaine, phencyclidine, etc.) and lung cancer risk and survival. Lead: M. Zhang, Z. Zhang, R. Hung, P. Boffetta
Machine learning methods to identify genetic variants and risk factors that discriminate between never smoking cases and controls. Lead: Monica E. Reyes, Matthew B. Schabath, Travis Gerke, Zuo-Feng Zhang, Qing Lan, Rayjean Hung, Olga Y. Gorlova
Vitamin D and lung cancer survival: a Mendelian randomization study. Lead: Mei Jiang, David Christiani, Rayjean Hung, Geoffrey Liu, Wei Xu
Mendelian Randomization Study of BMI, and the Moderating Effects on Inflammation, on Survival of Lung Cancer. Lead: Mei Jiang, Rayjean Hung, Chris Amos, Wen Zhou, Geoffrey Liu, Wei Xu
Evaluating change in BMI as a predictor for lung cancer risk. Lead: Wen Zhou, Geoffrey Liu, Quinn Ostrum, Jinyoung Byun, Younghun Han, Paul Brennan, Rayjean Hung, Chris Amos
Clinical predictors for EGFR mutation in Lung Cancer. Lead: Geoffrey Liu et al
Epigenome-wide survival analysis. Lead: D. Christiani
Clinical outcome based on Exome sequencing. Lead: R. Zhang, D. Christiani et al
Molecular overlap between COPD and lung cancer. Lead: M. Obeidat
Genome-wide Association Study of Small Cell Lung Cancer. Lead: Jyoti Malhotra, Paolo Boffetta, David Christiani
Identification of interacting genetics associated with early age at diagnosis in lung adenocarcinoma. Lead: L. Briollais
Tobacco specific constituents and lung cancer risk. Lead: Zuo-Feng Zhang
Somatic and genomic analysis. Lead: Chris Amos
Disease prediction from GWA data - utilising prior information of pathway analysis. Lead: Rayjean Hung, Nilanjan Chatterjie et al
Risk variant generalizability and effect modification. Lead: Loic Le Marchand et al